NOW (Bloomingdale, IL) continued its award-winning high quality testing program with a survey of 25 completely different model samples of methylcobalamin (methyl B12) bought on Amazon in January 2025.
Methyl B12 was chosen due to its excessive value and potential failure of its efficiency label declare. The outcomes as soon as once more recognized manufacturers not assembly label claims, however fewer than different dietary supplements NOW examined previously. All of the samples had been analyzed utilizing high-performance liquid chromatography (HPLC).
This spherical of testing highlighted that because of the “inherent complexity” of testing vitamin B12, even third-party testing labs might not be capable to produce constant outcomes, NOW mentioned.
Based on NOW, of the 23 manufacturers (not counting NOW’s two merchandise), 11 manufacturers exceeded their label claims with six testing above 120 %, 12 manufacturers examined beneath One hundred pc with three testing between 90-One hundred pc and three testing at 0-1 % efficiency.
The liquid and gummy varieties had been much less secure and tougher to investigate precisely in comparison with tablets and capsules. Just one product met efficiency whereas others ranged from 1 % to 105 %, NOW mentioned.
“Testing vitamin B12 is inherently difficult because of the instability of methylcobalamin and the issue in acquiring constant outcomes throughout varied matrices and dosage varieties. Contract laboratories typically wrestle with sustaining commonplace stability and correct analyte restoration, contributing to the variability noticed on this examine. Our inner information spotlight the business’s want for extra strong testing strategies and high quality management measures,” NOW mentioned.
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