A Bone to Choose

The bone & joint well being market is wanting youthful because it expands past older shoppers.

Bone and joint well being completed merchandise are seeing an uptick in demand amongst older and youthful shoppers alike. Shoppers are more and more conscious of bone and joint well being, and are enthusiastic about nature-derived dietary supplements that may protect bone density and joint operate. This rising consciousness is making a bone and joint well being market that appears youthful than ever earlier than. Whereas older shoppers nonetheless search out options for his or her current bone and joint well being points, youthful shoppers are taking a extra preventative strategy. Because the bone and joint well being market continues to develop, count on a wide selection of pure options to crop up that cater to this area of interest. Listed here are simply a number of the ways in which finished-product producers are capitalizing on rising demand for bone and joint well being merchandise.

Bone and Joint Well being Market on the Rise

The worldwide bone and joint well being market, value $4.74 billion in 2025, is predicted to extend at a compound annual progress price of seven.19 % by way of 2034, based on Priority Analysis. The analysis report in query notes that North America dominates the market with a 33 % share of income, whereas Asia Pacific is the fastest-growing new marketplace for bone and joint well being merchandise. Whereas nutritional vitamins preserve dominance within the bone and joint well being market, different elements like glucosamine are quickly rising.

Irritation and its Impression on Bone Density

Respiratory Is Not Elective!

Neil Levin, CCN, DANLA, senior vitamin training supervisor for NOW Well being Group in Bloomingdale, IL, famous that there have been will increase in gross sales of elements like turmeric, vitamin D3, vitamin K2 and omega-3 fish oils.

“We’re seeing progress in demand in a number of areas,” Levin stated. “As extra of the Child Boomer era hits senior citizen standing, these prepared to spend money on anti-aging regimens are wanting to strive merchandise that promise to maintain us versatile and transferring. However youthful folks, athletes particularly, even have challenges for joints and mobility.”

Because the bone and joint well being market grows, finished-product producers are capitalizing on this demand by diversifying their product strains. Lauren Clardy, senior director of branded elements for Maypro in Buy, NY, stated that whereas the trade continues to be embracing single-ingredient merchandise like glucosamine and chondroitin, savvy model leaders are creating multi-ingredient merchandise that present complete bone and joint assist. Ståle Søfting, gross sales and advertising and marketing director for GC Rieber in Norway, famous that profitable bone and joint well being merchandise regularly mix well-liked elements like calcium, vitamin D3, collagen, magnesium and extra. Søfting stated that many of those elements have synergistic results when mixed.

As bone and joint well being take precedence for shoppers, finished-product producers are responding with specialised dietary supplements that mix research-backed elements to each cut back irritation and assist joint operate. Xavier Berger, world market supervisor, mobility and joint well being for Gnosis by Lesaffre, stated that manufacturers are positioning these merchandise as proactive options for lively shoppers.

New Components Take Middle Stage

Whereas bone and joint well being mainstays like calcium and chondroitin are nonetheless well-liked amongst shoppers, rising new elements are making inroads available in the market, capturing each shopper curiosity and important market share. Levin defined that elements like vitamin K2 and collagen have skilled extra progress within the final a number of years than a number of the staple SKUs generally recognized to assist bone and joint well being; he pointed to the expansion of the natural class as a driving issue that has helped curcumin to reach the bone and joint well being class.

“Considered one of NOW’s best-selling joint well being merchandise is the UC-II undenatured Kind II collagen complement,” Levin famous. “NOW makes use of UC-II in a easy formulation, supplying 40 mg in a base of Aquamin, a seaweed-derived ingredient, in an easy-to-swallow capsule taken earlier than bedtime. Analysis signifies that Aquamin, a multi-mineral advanced, could assist correct bone mineralization and helps to manage key elements concerned within the regular immune system response to typical joint utilization.”

Different rising elements embrace a wide range of botanicals. Clardy famous that botanical elements like celery seed extract are gaining consideration in pure cures for joint ache and stiffness. The lively compound in celery seed extract, apigenin, seems to have anti-inflammatory and antioxidant properties. Clardy stated that apigenin has been discovered to be useful for joint ache, particularly in inflammatory circumstances like gout and rheumatoid arthritis.

“Maypro’s AppleActiv-DAPP helps joint consolation, encourages wholesome vary of movement, and promotes wholesome joint operate,” Clardy famous. “It does this by down-regulating inflammatory biomarkers, reminiscent of COX-2, IL-6 and TNF-alpha, whereas inducing constructive biomarkers, reminiscent of PCG-1 alpha. AppleActiv’s joint well being claims are supported by a 12-week pilot research.”

Clardy defined that the pilot research in query examined the consequences of AppleActiv-DAPP on serum antioxidant capability, vary of movement, and joint ache over the course of 12 weeks. The themes taking AppleActiv-DAP exhibited improved vary of movement in as little as two weeks, with statistically important reductions in joint ache after 4 weeks.

One other distinctive ingredient for joint well being is agmatine, a metabolite of the amino acid arginine. Gad M. Gilad, PhD, co-founder of Gilad & Gilad in Las Vegas, NV, stated that agmatine has been proven to advertise osteoarticular well being in each animal research and human scientific trials.

“Agmatine, with its postulated molecular shotgun impact, is exclusive as a result of as a single molecule it offers neuroprotection by modulating a number of molecular mechanisms vital for cell survival,” Gilad stated. “And importantly, agmatine exerts its salutary results with out inflicting undesirable negative effects.”

Gilad & Gilad presents two agmatine dietary supplements: AgmaSet, for people and AgmaVet, for veterinary purposes.

Different rising bone and joint well being dietary supplements symbolize a brand new tackle outdated elements. Søfting stated that GC Rieber has launched its branded VivoMega, a mixture of fish and algal omega-3 concentrates, for bone and joint well being. VivoMega delivers pure EPA and DHA omega-3s with out contaminants, utilizing marine-derived and vegan concentrates. In the meantime, Berger famous that Gnosis has launched MyCondro, a chondroitin sulfate ingredient for joint well being. MyCondro is sustainably derived by way of a patented fermentation course of moderately than from animal elements. The corporate additionally offers MenaQ7 vitamin K2 for bone well being.

“Bone loss happens naturally as we age, however with enough vitamin K2 consumption, this loss might be slowed,” stated Berger. “By activating vitamin Ok-dependent proteins already within the physique—osteocalcin and matrix Gla protein—MenaQ7 helps the physique correctly make the most of calcium. As soon as activated, osteocalcin binds calcium to the bone mineral matrix, resulting in stronger, denser bones.”

Sébastien Bornet, vp of worldwide gross sales and advertising and marketing for Horphag Analysis, the unique worldwide provider of Pycnogenol, stated that Horphag Analysis’s flagship ingredient has been extensively studied with greater than 160 scientific trials, making certain its security and efficacy as an ingredient.

“Pycnogenol is a novel supply of polyphenol compounds which are proven to guard cells from free radical injury related to degenerative circumstances,” Bornet defined. “It additionally works as a pure anti-inflammatory to assist joint well being. Most joint well being elements solely work by supporting cartilage well being to alleviate discomfort. In distinction, Pycnogenol turns to the basis of the issue, inhibiting the manufacturing of pro-inflammatory enzymes like 5-LOX and COX-2 along with supporting cartilage well being.”

Bornet defined that Pycnogenol has additionally been proven to help in nitric oxide manufacturing, enhancing blood microcirculation to hasten post-exercise restoration.

A wide range of different trending elements are hitting the bone and joint well being market. Caroline Farquhar is a medical advisor for CanPrev in Scarborough, ON, Canada. Farquhar stated that elements like hyaluronic acid and magnesium are trending for his or her anti-inflammatory properties in addition to their skills to assist joint mobility and promote bone density.

“CanPrev presents Nutritional vitamins D3 and K2, which work collectively to assist bone and joint well being by serving to regulate calcium within the physique,” Farquhar stated. “Vitamin D3 enhances calcium absorption, whereas vitamin K2 ensures calcium is correctly deposited in bones and never in gentle tissues. Vitamin K2, notably menaquinone-7, prompts osteocalcin to assist calcium deposition in bones and works with D3 to enhance bone energy. CanPrev’s D3 & K2 formulation characteristic the branded K2Vital, a pure, soy-free MK-7, suspended in coconut oil to boost absorption of those fat-soluble nutritional vitamins.”

Rising Analysis Reveals Promise

These new bone and joint well being elements are backed by scientific research that exhibit robust efficacy. Levin famous that one of the crucial substantial points going through the trade is that merchandise typically declare to have advantages, however don’t essentially have the science to again up these claims. Consequently, scientific analysis validating the consequences of bone and joint well being merchandise is important—and ingredient suppliers are assembly this want with sturdy scientific research.

One 2018 scientific trial on Eberbach, Germany-based Gelita’s branded Fortibone collagen ingredient, which is utilized in CanPrev’s Collagen Bone, assessed the consequences of 5 grams of Fortibone collagen peptides per day on bone mineral density. The research outcomes demonstrated a statistically important enchancment in bone mineral density relative to placebo. A follow-up open-label trial in 2021 confirmed that Fortibone supplementation will increase backbone bone mineral density in postmenopausal girls. Farquhar stated that over an prolonged therapy interval of three years, the Fortibone group demonstrated a 7 % enchancment in bone mineral density on the backbone and femoral neck.

Farquhar famous that additional analysis is suggesting a connection between bone well being and intestine well being:

“The position of intestine microbiota in bone metabolism is one other attention-grabbing space of analysis. The gut-bone connection has gained important consideration, however additional exploration is required to know the interactions between the intestine microbiota and bone well being.”

Different analysis has discovered that omega-3 fatty acid supplementation could have a protecting impact in opposition to bone loss. Søfting stated that larger fish and seafood consumption and better omega-3 blood ranges have been related to safety in opposition to osteoporosis in older males and postmenopausal girls. Now, rising analysis is confirming this impact. One 2023 meta-analysis of 9 randomized scientific trials and a couple of,070 sufferers with osteoarthritis demonstrated that day by day EPA and DHA supplementation relieved arthritis ache relative to placebo; the meta-analysis additionally discovered that EPA and DHA administration improved joint operate.

“Along with supporting the event of stronger bones, omega-3 has been attributed to rising calcium absorption and lowering inflammatory ache in joints,” Søfting famous. “Thus, omega-3 supplementation could play a big position in sustaining joint well being.”

Different rising analysis is figuring out the organic mechanisms that result in the elevated threat of osteoarthritis in postmenopausal girls, opening the door to doubtlessly simpler dietary dietary supplements. A 2025 animal research examined the hyperlink between estrogen and progesterone loss throughout menopause and extracellular matrix degradation and chondrocyte deterioration. The research discovered that restoring estrogen and progesterone ranges to pre-menopausal concentrations was protecting in opposition to cartilage degeneration.

“These findings provide insights that might inform the event of dietary dietary supplements or different interventions to assist joint well being throughout and after menopause,” Clardy stated. “This research offers a deeper understanding of how hormonal adjustments throughout menopause contribute to osteoarthritis, paving the way in which for potential therapeutic methods focusing on these mechanisms.”

Apparently, rising new analysis is displaying that bone and joint well being supplementation can are available in many varieties, together with topical patches. One 2017 research on Pycnogenol examined the efficacy of a topical patch model of the ingredient on joint irritation and discomfort in osteoarthritis sufferers. Topics utilized a topical patch containing 110 mg of Pycnogenol, or a placebo, on the painful space twice day by day for 3 weeks. The researchers evaluated osteoarthritis signs utilizing a mix of thermal imagery, strolling and standing capability, subjective ache scales and biomarkers like erythrocyte sedimentation price and C-reactive protein.

After three weeks, the topics utilizing the Pycnogenol topical patch exhibited substantial enhancements in ache scores, irritation, knee operate and swelling. Topical Pycnogenol administration was additionally related to diminished ESR and CRP ranges, demonstrating diminished inflammatory biomarkers. The research contributors within the Pycnogenol group additionally reported utilizing fewer NSAID (non-steroidal anti-inflammatory medication) ache relievers and a diminished want for physiotherapy.

Bornet defined that Pycnogenol is a potent antioxidant, and thus it alleviates joint discomfort by lowering underlying irritation. He famous that the ingredient additionally promotes pure collagen and hyaluronic acid manufacturing to cushion the joints.

Bone and Joint Well being Dietary supplements Get Cracking

Bone and joint well being elements are persevering with to diversify past conventional options like minerals and glucosamine, capitalizing on a rising demand for merchandise that may meet the wants of not solely getting older shoppers but in addition younger, lively shoppers who want to forestall future joint and bone well being points. As the marketplace for these merchandise grows at a fast tempo, ingredient suppliers and finished-product manufacturers are investing in each preclinical and scientific analysis to validate the advantages of their merchandise. New research are confirming the flexibility of assorted natural and non-herbal dietary supplements to enhance joint operate, cut back discomfort, improve bone mineral density and extra. Vitamin and complement retailers can make the most of this rising market by educating shoppers with the most recent analysis on rising elements whereas stocking merchandise with confirmed efficacy.VR