Whereas consultants typically agree that important fatty acids are helpful for human well being, some EFAs pose extra dangers than advantages. A 2018 research in Respiratory Analysis examined the consequences of arachidonic acid, an omega-6 polyunsaturated fatty acid, on pulmonary fibroblasts in human lung cells as in comparison with omega-3 polyunsaturated fatty acids, saturated fatty acids, and the obesity-associated cytokine TNF-alpha.
The research discovered that administration of arachidonic acid resulted in elevated expression of interleukin-6 and CXCL8 from fibroblasts in wholesome tissue, though this launch was diminished in COPD-affected tissue. The researchers additionally discovered that arachidonic acid diminished the basal deposition of fibronectin, sort I collagen, tenascin, and perlecan into the extracellular matrix in COPD fibroblasts. The research authors concluded that arachidonic acid has disease-specific results on irritation, and the response to arachidonic acid is impaired in sufferers with COPD. This research may clarify, partially, why weight problems seems to have a much less detrimental impact on COPD in comparison with different lung illnesses.
